Clinical significance of elevated fibrinogen in pregnant women

Fibrinogen is an indicator of our body's growth. We should try our best to balance the high fibrinogen levels in pregnant women. Maybe we are not very familiar with the problem of high fibrinogen levels in pregnant women. We pay less attention to this aspect, but high fibrinogen levels in pregnant women are closely related to our daily life. However, many people now have high fibrinogen levels in pregnant women. If the fibrinogen level in pregnant women is high, it will threaten our health, so we must find a way to balance it. Let us follow the article to understand the clinical significance of high fibrinogen levels in pregnant women.

Clinical significance:

1. Fibrinogen and liver diseases Fibrinogen is synthesized by the liver and is mainly distributed in plasma, but also exists in platelets and megakaryocytes. The normal plasma concentration is 1.5-3.5 g/L. Therefore, when the liver is severely damaged and the liver's fibrinogen synthesis function is impaired, the fibrinogen concentration in plasma decreases. Fibrinogen is a plasma glycoprotein synthesized by the liver. It can participate in the formation and development of thrombus and coronary artery. It is an indicator reflecting the state of thrombus and one of the independent predictors of acute coronary events. Increased fibrinogen indicates that the body's fibrinolytic activity is reduced, which promotes thrombosis.

2. Fibrinogen and nephrotic syndrome (NS) The changes in coagulation factors in NS patients are most obvious with the increase in fibrinogen levels. Fibrinogen levels may increase by up to 10 g/L due to increased synthesis, which is proportional to the amount lost in the urine, but the catabolism rate of fibrinogen is normal. There is a significant correlation between fibrinogen and cholesterol levels in NS patients, and both are negatively correlated with serum albumin levels.

3. Fibrinogen and atherosclerosis Fibrinogen and cellulose are closely related to the formation of atherosclerotic plaques. It is known that the fibrinolytic mechanism is affected by many factors, such as smoking, diabetes, and especially high serum triglycerides, which can cause an increase in plasma plasminogen activator inhibitor, thereby reducing the synthesis of plasminogen. The blood viscosity is relatively high, all of which are conducive to the formation of cellulose. Fibrinogen is an acute phase protein that enters the arterial wall from the blood as coagulation factor I. Under the action of thrombin, it is converted into fibrin monomers and subsequently cross-linked into fibrin. It can directly destroy endothelial cells and adsorb on the surface of red blood cells, increase the incidence of arterial thrombosis, and promote the rapid progression of atherosclerotic plaques. In addition, plasma fibrinogen can be deposited in the blood vessel walls, accelerating atherosclerosis. People have found that the amount of fibrin aggregates in the plaques of atherosclerosis is increased in both groups of diseases, and the blood viscosity is increased. Characteristics of atherosclerosis or even blockage.

The above content introduces us to the relevant situation of high fibrinogen in pregnant women. I believe that the above content satisfies the curiosity of many people. We should also know more about this aspect and understand how our nerves, brain and organs throughout the body work. I hope that the above content can make everyone have a clearer understanding of the problem of high fibrinogen in pregnant women. I hope everyone can grow up healthy and happy.