Treatment of malignant transformation of ovarian teratoma

In fact, many people may not be very familiar with the disease of ovarian teratoma malignant transformation, because this disease is not very common in life, but some female friends will suffer from this disease. Let us learn about the treatment methods of ovarian teratoma malignant transformation.

Treatment:

Once an ovarian teratoma is diagnosed, early detection and surgical resection must be performed to avoid the malignant transformation of the benign teratoma due to delay in scientific research and surgery. Detection can also prevent tumor infection, rupture, bleeding and complications. The key point of teratoma surgery is to completely remove the tumor. For ovarian and testicular tumors, one ovary or one testis is removed. For sacrococcygeal teratoma, it is emphasized that the coccyx must be removed at the same time to avoid residual pluripotent cells that may cause tumor recurrence.

The treatment principle of malignant ovarian teratoma is combined adjuvant therapy. After surgical resection, conventional chemotherapy for 1.5 to 2 years is usually used, including cisplatin, vinblastine or vincristine, and bleomycin. Since 2006, combination chemotherapy with cisplatin, doxorubicin, ifosfamide and other chemotherapy drugs has been recommended. Radiotherapy is only used for cases of malignant teratoma with clear microscopic or macroscopic residues. The appropriate radiotherapy dose for microscopic residues is 25 Gy, and 35 Gy can be used for macroscopic residues. For those who have undergone complete surgical resection, chemotherapy has been advocated as the main therapy in recent years, with radiotherapy used with caution to avoid delayed damage to reproductive organs and bone development during radiotherapy.

For patients with large or extensively infiltrated malignant teratomas that are clinically judged to be unresectable, preoperative chemotherapy or radiotherapy can be used to shrink the tumor before performing radical surgery, which is of positive significance in improving the surgical resection rate and preserving important organs. For advanced cases, preoperative chemotherapy or radiotherapy can also achieve the therapeutic goals of relieving tumor pressure, controlling metastases, and gaining the opportunity for reoperation.

Ovarian teratoma is generally asymptomatic clinically, but may cause abdominal distension, mild abdominal pain and compression symptoms as it grows. The contents of the teratoma are composed of a variety of mature tissues from 2 to 3 germ layers, most of which are ectoderm tissues. Therefore, squamous epithelium, sebaceous glands, sweat glands, hair and mature nerve tissue, as well as mesoderm fat cartilage and bone tissue can be seen in the cyst. About half of the ovarian dermoid cysts contain teeth.

The above article gives you a detailed introduction to the treatment methods for malignant transformation of ovarian teratoma. I believe that everyone has a basic understanding of it, so you should pay special attention to these issues in your daily life and go to the hospital regularly for a full-body physical examination.