Causes of uterine intramural fibroids

The uterus is of great significance to female friends. Once a female friend's uterus has some problems, it will not only cause harm to the female friend's body, but also easily affect the female friend's fertility. Therefore, we recommend that female friends must protect their uterus in daily life. Uterine intramural fibroids are a type of uterine disease, so what exactly causes the occurrence of uterine intramural fibroids?

Risk factors

There are many risk factors that contribute to the development or growth of uterine fibroids. Factors that increase the risk of uterine fibroids include: maternal use of estrogen during pregnancy, young age at menarche, nulliparity, late childbearing, obesity, African Americans, and tamoxifen. Factors that reduce the risk of uterine fibroids include exercise, multiple births, menopause, and oral contraceptives.

Sex hormones and their receptors

Modern medicine believes that uterine fibroids are hormone-dependent tumors. Uterine fibroids are common during the childbearing years, are rare before puberty, and shrink or disappear after menopause. Studies have shown that estrogen and progesterone synergistically promote the growth of fibroids. The main mechanism may be that estrogen in the follicular phase upregulates estrogen and progesterone receptors on uterine smooth muscle, and then progesterone promotes the mitotic activity of fibroids in the luteal phase, thereby stimulating the growth of fibroids.

Genetic factors

Cytogenetic studies have shown that 25-50% of uterine fibroids have cytogenetic abnormalities, including exchange of chromosome 12 and chromosome 17 fragments, rearrangement of chromosome 12, and partial deletion of chromosome 7.

Cytokines and extracellular mediators

There are increased expression levels of multiple growth factors and their receptors in uterine fibroids, which are considered to be mediators or effectors of the upregulation of ovarian sex hormones during uterine fibroid formation. However, the possibility of abnormal primary regulation of one or more growth factors cannot be ruled out. Uterine fibroids usually contain excessive extracellular media, which mainly contain fibroblasts and the collagen types I and III they produce. Myoma cells interact with fibroblasts and various growth factors, providing a suitable microenvironment for the formation and growth of myomas.

In the above article, we introduced the importance of the uterus to female friends. Female friends must protect their uterus well in daily life. Uterine intramural fibroids are a type of uterine disease. We analyzed the causes of uterine intramural fibroids in detail above.