What does human chorionic gonadotropin mean?

Human chorionic gonadotropin (HCG) is a glycoprotein metabolized by the trophoblast cells of the embryo. It is composed of α and β dimers of glycoprotein. The glycoprotein growth hormone with a content of 36700, the α subunit is basically similar to FSH (follicle-stimulating hormone), LH (luteinizing hormone) and TSH (thyroid-stimulating hormone) metabolized by the pituitary gland, so they can cross-react with each other, while the structure of the β subunit is different. Let’s take a look at what b-human chorionic gonadotropin means. I hope everyone can understand it.

In mature women, the fertilized egg moves to the uterus and the embryo implants to form an embryo. In the process of growing and developing into a fetus, the embryo transforms into trophoblast cells and produces a large amount of HCG, which can be excreted into the urine through the pregnant woman's blood circulation. When the pregnancy is 1 to 2.5 weeks, the HCG level in the blood cells and urine can rise rapidly, reaching a peak during the 8th week of pregnancy, and then drops to an upper medium level in the 4th month of pregnancy, and remains until the late pregnancy. The common testing methods at this stage are: latex inhibition test and hemagglutination inhibition test; radioimmunoassay (RIA); enzyme-linked immunosorbent assay (ELISA); monoclonal antibody colloidal gold test.

Clinical manifestations

The HCG test is of great significance for the diagnosis of early pregnancy, and has certain value in the diagnosis, differentiation and current medical history observation of pregnancy-related diseases, trophoblastic tumors and other diseases.

1. Increased levels are commonly seen in: early pregnancy, hydatidiform mole, malignant hydatidiform mole, choriosquamous cell carcinoma, seminoma, teratoma, and tumors with disordered HCG metabolism (such as gastric cancer, pancreatic cancer, lung cancer, colon cancer, liver cancer, ovarian cancer, gastrointestinal carcinoid, etc.).

2. Reduction is common in: miscarriage, etc.