Breast Carcinoma in Situ

Breast carcinoma in situ is a type of breast cancer and is also a disease that is very harmful to human health. If it is in the late stage, it may even pose a certain threat to the patient's life. There are not many methods to treat breast ductal carcinoma in situ, mainly surgical treatment and endocrine therapy. Next, I will introduce you to some relevant knowledge about breast ductal carcinoma in situ!

1. Ductal carcinoma in situ

Surgical treatment of ductal carcinoma in situ (DCIS) includes simple tumor resection and total mastectomy. Total mastectomy is the radical treatment for DCIS and approximately 98% to 99% of patients undergo this surgical treatment. Recurrence after total mastectomy is almost always invasive cancer, manifesting as local recurrence or no local recurrence with distant metastasis. Total mastectomy is the most effective treatment for DCIS, but for a DCIS patient who will never develop invasive cancer in her lifetime, this surgery may be overtreatment. The success of breast-conserving surgery for invasive breast cancer has led people to explore the possibility of using breast-conserving surgery to treat DCIS.

2. Surgical treatment of ductal carcinoma in situ

Surgical treatment for DCIS includes simple tumor resection and total mastectomy.

1. Total mastectomy is a radical treatment for DCIS, and approximately 98% to 99% of patients undergo this surgical treatment.

Recurrence after total mastectomy is almost always invasive cancer. It manifests as local recurrence, or no local recurrence but distant metastasis.

2. Breast-conserving surgery

Total mastectomy is the most effective treatment for DCIS. However, due to the inertness of DCIS, it may not progress to invasive cancer in a lifetime, so performing this surgery may be excessive.

The success of breast-conserving surgery for invasive breast cancer has led people to explore the possibility of using breast-conserving surgery to treat DCIS.

3. DCIS and endocrine therapy

1. The role of tamoxifen in the treatment of DCIS has been widely recognized.

Although the NSABP B24 study and the UK DICS study have different results, it is currently believed that breast-conserving surgery + radiotherapy followed by sequential tamoxifen treatment can reduce the incidence of invasive cancer and contralateral breast cancer compared with placebo.

2. The role of aromatase inhibitors in DCIS

Currently under research.