Cholestasis test for pregnant women

Bile is a hormone secreted by the liver. It has a normal range of values. If it exceeds this range, it will cause bile stasis, which has a great impact on the body. Especially for pregnant women, their bodies are very weak, and bile stasis will cause various symptoms. It will have a certain impact on the fetus in the womb. You should go to the hospital for cholestasis examination in time. So what specific examinations should be done?

The main symptoms of cholestasis in pregnant women are jaundice and skin itching. The severity and duration of jaundice vary depending on the cause. Skin itching usually occurs before jaundice appears, and the itching will disappear in the late stage of cholestatic liver disease. Long-term and severe cholestasis may cause xanthomas on the skin. Secondary manifestations of cholestasis include: steatorrhea caused by impaired absorption of human fat, bone disease caused by poor absorption of fat-soluble vitamins D, K, and A, night blindness, and bleeding tendency, etc.

Causes

1. Hemolytic jaundice

1. Congenital hemolytic jaundice such as hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency, hereditary pyruvate kinase deficiency, thalassemia, etc.

2. Acquired hemolytic jaundice such as autoimmune hemolysis, ABO blood type incompatibility transfusion reaction, neonatal hemolysis, hemolysis caused by drugs and chemical poisons, hemolytic streptococcal infection, etc.

2. Congenital non-hemolytic jaundice

Such as Gilbert syndrome, Crigler-Najjar syndrome, etc.

3. Post-hepatitis hyperbilirubinemia.

1. Hepatocellular jaundice such as viral hepatitis, schistosomiasis, alcoholic hepatitis, drug-induced liver injury, toxic liver injury, cirrhosis, physiological jaundice of neonates, and autoimmune hepatitis.

2. Intrahepatic cholestatic jaundice such as primary biliary cirrhosis, intrahepatic bile duct stones, metastatic liver cancer, common bile duct stones, bile duct cancer, acute cholecystitis, pancreatitis, biliary ascariasis, etc.

Diagnosis

When the serum bilirubin concentration is 17.1-34.2 μmol/L (1-2 mg/dl), but jaundice is not visible to the naked eye, it is called latent jaundice. If the serum bilirubin concentration is higher than 34.2 μmol/L (2 mg/dl), yellowing of the sclera, skin, mucous membranes and other tissues and body fluids is overt jaundice.