High-grade serous ovarian cancer

The incidence of ovarian cancer has been very high in recent years, and it is becoming younger and younger. Ovarian cancer is particularly harmful to health. There are many types of ovarian cancer. High-grade serous ovarian cancer is very common in normal times. People with high-grade serous ovarian cancer need to be actively treated. In life, many people do not know much about high-grade serous ovarian cancer. Can high-grade serous ovarian cancer be treated?

Can high-grade serous ovarian cancer be treated?

High-grade serous ovarian cancer is the most common type of ovarian epithelial cancer. It is highly malignant and prone to metastasis, so most patients are in the late stage when they seek medical treatment. Of course, there are a small number of patients who are discovered early due to accidental factors. For example, for patients whose cancer is confined to the ovaries and whose capsule is intact, the cure rate is close to 100%. If the capsule is incomplete, the cure rate may drop to 70-80%, and additional chemotherapy will be required after surgery.

If pelvic and abdominal metastasis occurs, the stage may be IIA or above, with IIIC being the most common, and a small number being IVB. This type of advanced patients usually requires an individualized treatment plan, which is generally a combination of surgery and chemotherapy. The surgery is what is commonly known as radical resection of ovarian cancer, and chemotherapy is mainly based on the TC regimen. Through surgery combined with chemotherapy, the five-year survival rate of advanced high-grade serous ovarian cancer is 30%-60%. With the development of clinical trials of targeted drugs and various new drugs, the survival rate will be further improved.

Difference between low-grade and high-grade serous ovarian cancer

Ovarian serous tumors are ovarian epithelial tumors with malignant potential that are between benign adenomas and carcinomas. Its characteristic is that cystic tumors can be seen, with diameters ranging from 1 to 20 cm; they are usually unilocular but can also be multilocular. The cyst fluid is mostly clear straw yellow, serous, and occasionally turbid or even bloody. There are many changes in growth patterns and morphology, especially papillary growth, which is more common and diverse in patterns. Bilaterality is more common than other types of epithelial tumors. The tissue types can be divided into cystadenoma, papillary cystadenoma, superficial papilloma, adenofibroma and cystic adenofibroma among benign and borderline tumors. Malignant tumors can be divided into adenocarcinoma, papillary adenocarcinoma, superficial papillary adenocarcinoma, adenocarcinoma fibroma and cystadenocarcinoma fibroma.

For patients with advanced serous ovarian cancer, survival is better with low-grade types than with high-grade types. For patients with low-grade serous carcinoma, lymph node dissection significantly improves prognosis, but chemotherapy does not.