The process of the second test tube transplant

In vitro fertilization is a relatively mature reproductive technology today. It is a better choice for many people who cannot conceive through normal means. Of course, test tube transplantation does not succeed in one go. If the first transplant is unsuccessful, a second transplant will have to be performed. So, what is the process for the second test tube transplant? This will be introduced below!

1. Step 1: Endometrial Preparation

First of all, in the menstrual cycle that decides to perform frozen embryo transfer, endometrial preparation should be performed first. The endometrial preparation methods include:

1. Natural cycle

It is used for patients with regular menstrual cycles and normal ovulation. That is, vaginal B-ultrasound and ovulation test strips are used to monitor follicle development and ovulation starting from the 10th to 12th day of menstruation, and luteal support is started on the day of ovulation. Transplant the thawed embryos on the 3rd day after ovulation, and select 2 to 3 high-quality embryos for transplantation.

2. Ovulation cycle

For patients with abnormal ovulation, take clomiphene or letrozole orally from the 5th day of menstruation for 5 days, and add Progynova if necessary. B-ultrasound monitors the endometrium and follicles. When the thickness of the endometrium reaches 8-12mm, HCG is injected and ovulation will occur 48-36 hours later. Luteal support begins on the day of ovulation. Transplant the thawed embryos on the 3rd day after ovulation, and select 2 to 3 high-quality embryos for transplantation.

The ovulation induction plan depends on your individual situation. Doctors in different hospitals may use different plans, including the above-mentioned Clomiphene (Letrozole) + Progynova plan, Clomiphene (Letrozole) + HMG plan, HMG plan and many other plans. You can just follow the doctor's requirements. The overall goal is to prepare your endometrium and hormone levels to welcome the arrival of the embryo.

2. Step 2: Treatment of the endometrium

Endometrial scraping, hysteroscopic surgery or intrauterine drug infusion; hysteroscopy clearly shows the morphology, thickness, location and range of lesions of the endometrium, significantly improves the detection rate of endometrial lesions, and provides treatment at the same time.

Studies have reported that endometrial stimulation or intrauterine perfusion can stimulate endometrial reproduction, regulate the local internal environment of the endometrium, improve endometrial receptivity, and increase embryo implantation rate and clinical pregnancy rate, possibly through micro-"injuries".

Step 3: Embryo Transfer

For you, the transplantation procedure for frozen embryo transfer and fresh embryo transfer is no different. After the transplantation, luteal support is still required, but the dosage can be less than that for fresh cycle embryo transfer. The doctor will also adjust the dosage according to your individual situation and use it according to the doctor's requirements.

The process and precautions you need to be aware of are the same as for fresh embryo cycle IVF embryo transfer.

4. Step 4: Pregnancy test

Finally, 14-16 days after the transfer, it’s time for the “prize draw,” just like a fresh cycle embryo transfer.

The success rate of fresh embryo transplantation for in vitro fertilization is around 40%-50%, and the success rate of frozen embryo transplantation after thawing is close to 70%, which is mainly determined by the mother's physical condition. When fresh embryos are transferred, the mother has undergone damaging steps such as egg retrieval, and the recovery of the endometrium may not be ideal. However, when frozen embryos are transferred, the mother has recovered and rested, and the condition of the uterus is more conducive to conception.