What causes corpus luteum insufficiency?

When facing the problem of corpus luteum insufficiency, everyone should pay attention to it and analyze and understand the causes, such as the existence of some reproductive diseases, or insufficient progesterone. Changes in endometrial secretion will affect women's reproductive health.

1. For women with luteal insufficiency, the corpus luteum begins to shrink 4 to 5 days after ovulation, and the second half of the menstruation is shortened accordingly. After ovulation, the corpus luteum continues to secrete progesterone. Usually 8 to 10 days after ovulation, if the egg is not fertilized, the corpus luteum begins to shrink. Usually, this menstrual cycle is also relatively deficient in estrogen, causing poor development of the endometrium and thus preventing the fertilized egg from implanting. Luteal insufficiency refers to insufficient estrogen and progesterone secretion by the corpus luteum, resulting in insufficient secretory changes in the endometrium.

2. Repeated spontaneous abortion can lead to luteal insufficiency. During the first three months of pregnancy, corpus luteum function is particularly important. During this stage, the corpus luteum secretes high levels of hormones, which can cause the endometrium to proliferate and thicken, providing a favorable environment for embryo implantation.

3. It is generally believed that luteal insufficiency is related to the following factors: ① Insufficient secretion of follicle-stimulating hormone during the follicular phase and low levels of follicle-stimulating hormone and estradiol in the follicular fluid. ②The luteinizing hormone peak during ovulation is insufficient. ③ Insufficient secretion of luteinizing hormone during the luteal phase or its pulsatile secretion is insufficient. ④ Abnormal steroid hormone receptors in endometrial cells lead to low responsiveness to hormones secreted by the corpus luteum, which can cause normal corpus luteum function and endometrial hypoplasia.

4. Luteal insufficiency cannot maintain normal pregnancy. Vaginal insertion of progestin-containing suppositories during the second half of the menstrual cycle and the first three months of pregnancy can help improve luteal function. Artificial progestins must be avoided. For example, the use of medroxyprogesterone and norethindrone in early pregnancy may be harmful to the fetus.