What causes endometrial hyperplasia?

Endometrial hyperplasia is related to many factors, such as common endocrine functional tumors, excessive obesity, and complex endometrial hyperplasia, which may all be related to it. Therefore, it is necessary to pay attention to hospital examinations and make correct and reasonable adjustments after clarifying the causes.

1. Endocrine tumors: Functional endocrine tumors may be rare, but they can also cause endometrial thickening. The gonadotropin function of the pituitary gland is abnormal, and ovarian granulosa cell tumors are also tumors that continuously secrete estrogen.

2. Obesity. The adrenal glands can secrete a substance called estrenedione, which can be converted into estrone through adipose tissue. The more adipose tissue there is, the stronger the conversion ability is. The higher the level of estrone in the plasma, the more estrogen is secreted, and the more likely the endometrium will thicken. Obese women have more adipose tissue, so the level of estrogen is also high, and the thickness of the endometrium is correspondingly greater.

3. Simple endometrial hyperplasia refers to a significant thickening of the endometrium, sometimes in a polyp-like form. The microscopic lesions are diffuse, with both the stroma and glandular hyperplasia. The amount of curettage material is large.

4. Complex endometrial hyperplasia. The diseased uterus may be thickened or very thin, or it may be polyp-like. Different from simple hyperplasia, focal hyperplasia consists of glandular components without involving the stroma. Hyperplasia may be related to the distribution of hormone receptors in the tissue, and the amount of curettage material can be more or less.