How to check endocrine disorders? Women must watch

Many women will experience symptoms of endocrine disorders in life. This symptom has a great impact on women's health and may induce a series of female diseases, so timely conditioning is particularly important. So how do you check female endocrine disorders?

1. Hormone concentration measurement

The hormone concentration in body fluids can be measured by radioimmunoassay, enzyme-linked immunosorbent assay, etc. The reliability of the assay is determined by the purity and characteristics of the antibodies and the quality of the collected samples. For example, when measuring the insulin concentration in the blood, proinsulin is also included, and when measuring the blood C-peptide, the undissociated C-peptide is also included, all of which affect the reliability of the measurement results. The resolution can only be improved when monoclonal antibody detection is used. In addition, it is also necessary to distinguish between free hormones (mostly biologically active) and bound hormones (mostly biologically inactive) in body fluids in order to correctly evaluate the test results.

2. Hormone dynamic observation

Determine the normal rhythm of hormone secretion, such as the diurnal fluctuations of ACTH and cortisol, the monthly rhythms of luteinizing hormone and follicle-stimulating hormone, etc. The disappearance of normal rhythm is often an early sign of glandular dysfunction.

3. Hormone regulation function test

It includes excitation tests (to check the response to trophic hormones) and inhibition tests (to check feedback inhibition function), which are of great significance in distinguishing physiological changes from pathological changes and clarifying the nature of pathological changes.

3. Receptor Assay

Determination of the quantity and quality of various target cell receptors, such as red blood cell insulin receptor determination, blood cell nuclear T3 receptor determination, etc. It is mainly used for patients whose hormone hydrops is inconsistent with clinical manifestations. The rhythm of receptor changes also has important clinical significance.

4. Target cell function test

Only the response of target cells can reflect the abnormal function of endocrine glands clinically, so measuring the function of target cells can objectively evaluate the effects of hormones. For example, in hyperthyroidism, platelet potassium-sodium ATPase activity is significantly increased, the myocardial isovolumetric contraction period is shortened, and the basal metabolic rate is increased.