How high should the D2 polymer be before a pregnant woman can take medication?

The d2 polymer is a specific lytic substance formed by chemical cross-linking of free fatty acids with activated factor XIII and then hydrolysis by plasmin. It is a specific marker of the entire fibrinolytic process. D-dimers are derived from chemically cross-linked free fatty acid bonds that are cleaved by plasmin.

D-dimer can be used as a quantitative analysis indicator of the actual thrombolytic effect, while FDP (fibrinolytic protein/protolytic substance) can be derived from fibrinogen and also increases in primary fibrinolysis. Therefore, the latter cannot be used as a quantitative indicator of thrombolytic effect. However, the gold latex-stained D-dimer immunoassay is sensitive to various complex D-dimer fragments, such as X-fragment complex D-dimer derived from fibrinolytic protein, thus reducing the specificity of the experiment. The specific clinical performance of this determination method in quantitative analysis and detection still needs to be confirmed by a large amount of clinical nursing materials.

D-dimer or FDP measurement can be used as an auxiliary diagnosis for some diseases with improved thrombolytic specificity, such as DVT, DIC, renal function decline and thrombolytic efficacy differentiation. Theoretically, DIC shows that the small debris produced by fibrinolysis is not sensitive to the FDP assay, while the D-dimer test is relatively sensitive. Therefore, the sensitivity of a specific test method in post-symptom situations still needs to be verified by clinical data.

D-dimer can be collected from hemagglutination specimens (blood), while FDP can be collected from blood cell specimens. The latter is affected by whether blood cell production is complete.

The FDP natural latex particle method was tested for 3 minutes, and the D-dimer colloidal gold immune filtration method was tested for 2 minutes. The former is a semi-quantitative measurement, and the latter can be comparable to the ELISA method if a reader is used.

D-dimer is an indicator in coagulation test. Because the coagulation function indicators in the blood of pregnant women are on an upward trend, pregnant women are in a hypercoagulable state during pregnancy. This is a normal physiological change to prepare for future delivery and prevent postpartum hemorrhage.

The standard value of D-dimer is different in different weeks of pregnancy, and the standard values ​​of each hospital laboratory are also different. Generally speaking, the standard value of D-dimer in pregnant women is 550 ug/L in the early pregnancy, 2500 ug/L in the middle pregnancy, and 3500 ug/L in the late pregnancy. If the D-dimer continues to rise and is significantly abnormal compared to the standard value, the cause should be found, such as immune system disease, leg vascular vein obstruction, and a professional doctor should be sought for evaluation and causal treatment.