Pregnant women's alkaline phosphatase is more than 200

A significant increase in alkaline phosphatase usually indicates that the patient has biliary obstruction. Liver function test results will generally show a significant increase in glutamyl transpeptidase. Severe obstruction may cause an increase in total bilirubin and direct bilirubin. Color Doppler ultrasound examination of the gallbladder and liver system can reveal manifestations of obstruction such as systemic stones. First, the patient can be given traditional anti-inflammatory and choleretic treatment to observe whether the stones can be discharged spontaneously, and endoscopic ERCP stone removal treatment can be performed if necessary.

Alkaline phosphatases are commonly found in the body's bones, intestines, liver, kidneys, and embryos. The standard value of blood cell alkaline phosphatase is generally between 45-125U/L. If the alkaline phosphatase is 200U/L, it is considered as elevated alkaline phosphatase. Some physiological factors can cause an increase in alkaline phosphatase, such as pregnant women, or infants, children, and adolescents in the bone marrow development stage, as well as a short-term high-fat or high-sugar diet, which can lead to higher test values ​​of blood cell alkaline phosphatase. Physiological factors may be common in various hepatobiliary diseases and bile duct and common bile duct diseases, fracture recovery period or osteomyelitis, etc., which can also cause an increase in alkaline phosphatase.

If the patient's liver function test shows that the alkaline phosphatase is 200U/L, if it is a simple increase in alkaline phosphatase, there will be no major clinical manifestations. However, if the patient's alkaline phosphatase is elevated, combined with an increase in total bilirubin, especially an increase in direct bilirubin, then we should consider whether the patient has bile duct obstruction. If the patient's total bilirubin exceeds 34.2umol/L, and the bilirubin level is directly high, and there is an increase in alkaline phosphatase and GGT, then the patient is highly suspected of having gallstones or space-occupying lesions in the gallbladder.

The cause of obstructive jaundice needs to be further established. If necessary, the patient needs to undergo magnetic resonance imaging of the bile duct, i.e. MRCP, and ERCP, and contrast examination under ERCP. If stones are confirmed, they need to be removed by balloon expansion, or if space-occupying lesions are detected, a film should be taken for pathophysiological diagnosis if necessary.