How to prevent hemolysis if the woman has type O blood

O-type blood is a very common blood type, but women with O-type blood need to pay more attention when they are pregnant to prevent hemolytic disease in the fetus. Not all babies born to mothers with type O blood will develop hemolytic disease. It's just that some babies will develop the disease while others will not; some symptoms are mild while others are severe. This is related to the amount of maternal antigen, the degree of fusion of antigen with fetal blood cells, the strength of antigen and the compensatory hematopoietic capacity of the fetus.

ABO hemolytic disease usually occurs in the second pregnancy, but it may also occur in the first pregnancy in some cases. This is because there are substances similar to the A (B) antigen in nature, which O-type blood mothers are often exposed to before pregnancy. These similar blood antigen substances can then stimulate O-type blood mothers to produce A (B) antigen. During pregnancy, this antigen can enter the fetus through the embryo and cause hemolysis.

1. The key target of neonatal hemolytic disease is the fetus whose mother's blood type is O type, and whose father's blood type is A, B, or AB type. If a couple is in this situation, they need to check the antigen titer during pregnancy when they are pregnant. The index value of the antigen is 1:64. If the test shows that the titer of the antigen reaches 1:128 or 1:256, hemolysis is likely to occur. At this time, treatment needs to be started. The doctor will give the patient medicine or injections, and the patient will usually recover during delivery.

2. Some babies still do not recover after treatment during pregnancy, so they need to be treated again after birth. If a woman has had miscarriage, anemia, edema, or neonatal jaundice in the past, it is very likely that this is caused by the incompatibility of the blood type with the fetus.

Women with type O blood should be careful to prevent hemolysis in the fetus when they are pregnant. If the baby is a key target, preventive measures should be taken to avoid the occurrence of fetal hemolytic disease.