What is the relationship between progesterone and estradiol?

People who have given birth should be familiar with the terms progesterone and estradiol. These are two very important hormones for women after they become pregnant, and they have a great impact on the bodies of pregnant women and fetuses. After a woman becomes pregnant, she will pay special attention to checking the values ​​of these two items. Many people have doubts about whether there is a relationship between these two hormones. The following is a detailed introduction to the relationship between progesterone and estradiol.

Generally speaking, several hormones in the body of pregnant women have certain effects on pregnancy and the growth and development of the baby. They must be maintained at a certain level, otherwise it is easy to cause fetal arrest or miscarriage.

Physician's analysis:

There is no direct relationship between estradiol and progesterone. HCG controls the fetal heart rate, estradiol controls the fetal bud, and progesterone prevents the uterus from bleeding and avoids flushing the embryo out. HCG needs to keep rising, estradiol must be above 700 to have a chance of embryo formation, and progesterone must be between 25 and 60 to be safe.

Physician's advice:

It is recommended to check the levels of various hormones during pregnancy. If they are low, they need to be supplemented, and attention should also be paid to the supplementation of other elements.

Progesterone effects

Progesterone is a biologically active progestogen secreted mainly from the ovaries. The amount of progesterone produced per day before ovulation is 2-3 mg. After ovulation, it rises to 20-30 mg per day, which promotes the growth of endometrial glands and thickening of the endometrium to prepare for the implantation of the fertilized egg. During pregnancy, it can reduce uterine excitability, inhibit its activity, relax smooth muscles, and provide support and protection for the early growth and development of the fetus. In addition, progesterone and estrogen act synergistically. Estrogen promotes the development and maturation of female secondary sexual characteristics, while progesterone further promotes the development and maturation of secondary sexual characteristics based on estrogen.

Estradiol Effects:

Estradiol is a natural estrogen secreted mainly by mature ovarian follicles in the body. It can promote and regulate the normal development of female sexual organs and secondary sexual characteristics. Its main pharmacological effects are: ① Promote endometrial hyperplasia; ② Enhance the contraction of uterine smooth muscle; ③ Promote the development and proliferation of mammary ducts, but larger doses can inhibit the release of prolactin from the anterior pituitary, thereby reducing milk secretion; ④ Anti-androgenic effect; ⑤ Lower blood cholesterol and increase calcium deposition in bones. This product can be absorbed from the gastrointestinal tract and skin, but it is easily destroyed when taken orally, so it is mainly used for intramuscular injection and external application. When applied topically, estradiol penetrates the skin directly into the blood circulation, avoiding first-pass metabolism in the liver and not damaging liver function. This product is metabolized into weaker active estrone and estriol in the body, and is inactivated after combining with glucuronic acid and sulfuric acid and excreted in the urine.