Low-grade squamous lesions plus HPV negative

Cervical cancer is a common malignant tumor in women. When patients with cervical cancer are examined, comprehensive results are usually not obtained. Some of them may initially be low-grade squamous lesions, and in the end they will be tested HPV negative. This test result indicates that they have been infected and caused cervical cancer, which mainly includes unhygienic sexual life, multiple abortions, or severe trauma to the uterus, etc.

Cervical cancer is the most common malignant tumor in women, with a high incidence rate between the ages of 30 and 55. With the promotion of scientific knowledge among today's female friends, the view that HPV infection can cause cervical cancer has been accepted by many people. However, for those who are HPV-negative, whether they will develop cervical cancer or not may be a problem that many women may be confused about. The following is a discussion on this issue:

To discuss the question of whether HPV-negative people can develop cervical cancer, we must start with the causes of cervical cancer. Cervical cancer is related to HPV infection, but it is not only related to HPV infection. It is also related to many factors, such as early sexual activity (having a history of sexual activity before the age of 18), too many sexual partners, multiple births, multiple miscarriages, unhygienic sexual life, etc. are all causes of cervical cancer. Therefore, people who are HPV-negative may also develop cervical cancer.

Cancer is caused by multiple factors and long-term stimulation. HPV infection is only one of the causes. After HPV infection, the cervical tissue is easily damaged due to repeated stimulation of the virus, leading to malignant transformation. Cancer is caused by DNA mutation during the process of tissue damage and repair, which leads to abnormal expression of proteins. Proteins are biological functions. When proteins are expressed abnormally, cells cannot differentiate into normal cells normally, and they appear in an immature state and continue to proliferate, forming malignant tumors.

From the perspective of the development of cervical cancer, cervical damage and repair are the most important processes, and HPV infection is not the only factor. Any factor that can cause cervical damage is the cause of cervical cancer and may cause cervical cancer. HPV infection is a cause of cervical cancer. Therefore, people who are HPV negative may also develop cervical cancer.