Will progesterone be high in molar pregnancy?

Hydatidiform mole is a very serious disease that threatens the health of many people. Hydatidiform mole not only means that the baby cannot be conceived normally, but also has the risk of bleeding. Many people are affected by hydatidiform mole and suffer great psychological and physical trauma. Hydatidiform mole can be treated clinically through correct means, during which the patient must cooperate with the doctor's instructions. So, will the progesterone level in molar pregnancy be high?

Will progesterone level rise during molar pregnancy?

Complete hydatidiform mole may be related to factors such as region, race, nutrition, socioeconomic factors and gestational age. Partial hydatidiform mole may be associated with the use of oral contraceptives and menstrual disorders. Once a hydatidiform mole is discovered, you cannot have children. All patients with hydatidiform mole should be advised to follow up regularly. It is best to keep in touch with the hospital for a long time. More importantly, regular check-ups within 2 days are aimed at early detection of malignant changes, but sometimes there may be residual vesicular fetal masses. Patients should be advised to take effective contraceptive measures for at least 2 years and should be checked monthly for the first six months. If irregular vaginal bleeding, hemoptysis, headache or other discomfort occurs, you should go to the hospital for examination immediately.

Hydatidiform mole has a high risk factor. If you want to avoid this situation as much as possible, you should start from the most basic aspects that you can do, such as going to a regular hospital for a comprehensive pre-pregnancy check before pregnancy. The doctor will give you suitable advice based on your physical condition. In addition, you should supplement with enough vitamins and folic acid before and during pregnancy, and try not to get close to viruses to avoid infection. This will greatly reduce the chance of hydatidiform mole. Below we will briefly understand some basic knowledge about hydatidiform mole chemotherapy.

Differential Diagnosis

1 HCG determination

Due to the proliferation of trophoblastic cells, a large amount of HCG is produced in hydatidiform mole. The HCG concentration in the serum is much higher than the value in the corresponding month of normal pregnancy. Therefore, this difference can be used as an auxiliary diagnosis of hydatidiform mole. Since the peak of HCG secretion in normal pregnancy is between 60 and 70 days, which may coincide with the onset of hydatidiform mole, diagnosis is difficult. However, if HCG can be measured continuously or B-ultrasound examinations can be performed at the same time, differentiation can be made.

2 Flow cytometry (FCM)

The karyotype of complete hydatidiform mole is diploid, while that of partial hydatidiform mole is triploid.

3 Ultrasound examination

In a normal pregnancy, the gestational sac can be seen at 4-5 weeks of pregnancy, the heart beat can be seen at 6-7 weeks of pregnancy, the fetal heartbeat can be detected as early as 6 weeks of pregnancy, and can be heard after 12 weeks of pregnancy. In hydatidiform mole, the uterine cavity appears as coarse dots or falling snow. No gestational sac is visible, and there are no fetal structures or fetal heartbeat signs. Only uterine blood flow murmurs can be heard, but no fetal heartbeat.

Once the diagnosis of hydatidiform mole is confirmed, it should be cleared immediately. When removing a hydatidiform mole, care should be taken to prevent excessive bleeding, uterine perforation and infection, and the chance of subsequent malignant transformation should be reduced as much as possible.