What are the symptoms of ovarian failure?

The ovaries are an important part of the female reproductive organs. They have many functions for women, such as synthesizing estrogen, secreting estrogen, and expelling eggs. Only when the female ovaries can function normally can they complete the task of passing on the family line. Because women usually do not pay attention to the care of their ovaries, they may suffer from ovarian failure. What are the symptoms of ovarian failure? Let's introduce them below.

Typical symptoms:

1. Amenorrhea is divided into primary amenorrhea and secondary amenorrhea. Secondary amenorrhea occurs before the age of 40. There are no characteristic signs of menstrual abnormalities before amenorrhea in POF patients. Some women suddenly experience amenorrhea after regular menstruation, some experience amenorrhea after stopping birth control pills or giving birth, and some experience irregular menstrual cycles and periods before amenorrhea.

2. Infertility is the main reason for patients with premature ovarian failure to seek medical treatment and suffer. There are primary infertility and secondary infertility.

3. Symptoms of low estrogen. Symptoms of low estrogen are rare in patients with primary amenorrhea. If they occur, they are mostly related to previous use of estrogen replacement therapy. Symptoms of low estrogen are common in patients with secondary amenorrhea.

[Other symptoms]

Concomitant autoimmune diseases include Addison's disease, thyroid disease, diabetes, lupus erythematosus, rheumatoid arthritis, vitiligo, and Crohn's disease. There are also insidious symptoms of adrenal insufficiency, such as recent weight loss, loss of appetite, vague abdominal pain, weakness, increased skin pigmentation, and salt cravings.

treat

[Treatment policy]

Estrogen-progesterone replacement therapy, osteoporosis prevention, ovulation induction therapy, immunotherapy, donated egg embryo transplantation, etc. can be used as appropriate.

[Drug treatment]

1. Estrogen-progesterone replacement therapy (HRT)

Estrogen-progesterone replacement therapy is very important for young POF patients. It can relieve the symptoms of low estrogen and urogenital tract atrophy, prevent long-term complications, and reduce the risk of colon cancer by 37%. 2. Prevent osteoporosis

In addition to HRT, ensure 1200 mg of calcium intake per day. Vitamin D 400～800IU/d, and engage in necessary physical exercise. 3. Ovulation induction therapy

Generally, after HRT or GnRHa is used to suppress endogenous gonadotropin to a lower level, sufficient hMG/hCG is given to induce ovulation while monitoring by ultrasound. The dosage of hMG is required to be large and the duration is long.

[Surgical treatment]

1. To date, donated egg embryo transfer is still the most effective treatment for POF patients to achieve pregnancy. 2. Ovarian transplantation.