Why do follicles become luteinized?

If the follicles are luteinized, it will directly affect women's normal reproductive health. The causes of follicle luteinization include central endocrine disorders or local disorders, such as endometriosis, pelvic inflammatory disease and other gynecological inflammations.

1. What does luteinization of follicles mean?

1. The full name of luteinized follicle is luteinized unruptured follicle syndrome (LUFS for short), which means that the follicle is mature but not ruptured, the oocyte is not discharged but luteinized in situ, forming a corpus luteum and secreting progesterone, and a series of changes similar to the ovulation cycle occur in the effector organs of the body. Women with luteinized follicles have normal menstrual cycles and similar ovulation symptoms but remain infertile. This is a special type of anovulatory menstruation and is one of the important causes of infertility.

2. Treatment methods vary from person to person, and are often based on inducing ovulation. The most commonly used method is hormone supplementation. If the follicles do not rupture after several months of using ovulation-inducing drugs, in vitro fertilization may be necessary. The cause of LUFS is still unclear. Most scholars believe that it is related to central regulation disorders, local disorders, and mental and psychological factors. Most people believe that the incidence rate is about 5% to 10% during the natural menstrual cycle and about 30% to 40% during the drug-induced ovulation period.

2. Causes of luteinization of ovarian follicles

1. Central endocrine disorders.

Ovulation is a complex process involving the coordinated action of multiple hormones. Central endocrine disorders can directly affect the growth and development of follicles and the occurrence of ovulation.

2. Local obstacles.

Endometriosis, pelvic inflammatory disease, etc. can cause pelvic adhesions, resulting in non-rupture of follicles and no ovulation. Studies have shown that luteinization of follicles after ovarian surgery is mainly related to sparse membrane-like adhesions on the surface of the ovaries.

3. Enzyme or kinase deficiency or defect or prostaglandin deficiency.

The production of enzymes is also the cause of follicle luteinization. Insufficient enzymes or kinases will reduce the activity of fibrin and plasminogen activator in the ovaries, which can reduce the activity of plasminogen on the pre-ovulatory follicular cells, affecting the dissolution of fibrin and the self-function of the follicle wall. Proteolytic enzymes also play a role in follicle rupture, and the lack of these enzymes inhibits ovulation.

4. HyperPRLemia. PRL can inhibit ovarian secretion and reduce the ovarian response to GnRH, making ovulation impossible.