Pregnant women's peroxidase antibody is more than 400

TPOA directly resists thyroid lactate dehydrogenase (TPO). TPO catalyzes the iodination of tryptophan in thyroid serum protein during the process of microbial production of T3 and T4. Studies have confirmed that TPO is the main component of thyroid microsomal antigens and TPOA is a specific component of TMA. Therefore, TPOA present in the patient's body is TMA.

TPOA is closely related to the occurrence and development of autoimmune thyroid disease (AITD). It can cause autoimmune-related hypothyroidism by causing insufficient thyroid hormone metabolism through cell-mediated and antigen-dependent cytotoxic functions. As an indicator for the diagnosis and detection of autoimmune thyroid disease, TPOA has higher sensitivity, specificity, reliability and significance than TMA, and has become the preferred indicator for diagnosing autoimmune thyroid disease. The main clinical applications of TPOA: diagnose Hashimoto's disease (HD) and autoimmune disease hyperthyroidism; treat diffuse goiter (Graves); monitor the effectiveness of immunotherapy; test the possibility of thyroid disease in families; predict the occurrence of thyroid hormone deficiency in pregnant women after childbirth.

Features

For patients with primary hypothyroidism, combined with elevated TSH, patients with early hypothyroidism can be detected. For patients with abnormal hypothyroidism, if TPOA increases, it is helpful to distinguish primary from secondary hypothyroidism. For HT patients, TPOA exists throughout life. If the clinical symptoms are typical and TPOA persists for a long time, it can be used as a basis for diagnosis.

For patients who are suitable for thyroid replacement therapy, including those with elevated TSH levels and positive anti-thyroid lactate dehydrogenase TPOA, clinical collaborative testing of TPOA and TGA is mainly used to identify the effectiveness of immunotherapy, to determine the likelihood of disease in people with family thyroid disease, and to predict the occurrence of thyroid dysfunction in pregnant women after childbirth.

Testing TPOA helps to address diagnostic difficulties, such as abnormally high TSH levels with normal levels of diffuse T4 (FT4). If TPOA is elevated, subclinical hypothyroidism and early diffuse reticulocytic thyroiditis should be considered. Low levels of TPOA occur in 10% of asymptomatic patients, indicating susceptibility to thyroid autoimmune diseases; 85% of hyperthyroidism and hypothyroidism patients show high levels of TPOA. Therefore, in the diagnosis of most thyroid autoimmune diseases, the combined testing of TPOA and TGA has a higher clinical value.

In addition, TPOA may be positive in patients with postpartum thyroiditis, atrophic thyroid cysts, and some nodular goiter; some autoimmune diseases such as rheumatoid arthritis and lupus erythematosus can also show increased TPOA.