What causes polycystic ovary?

Polycystic ovary is a common disease, more common in women aged 20-50. Because most of them are benign, some of them will disappear on their own. Polycystic ovary syndrome is generally caused by two reasons, hereditary and non-hereditary.

At present, there are two kinds of research on the etiology of PCOS: non-genetic theory and genetic theory.

Non-genetic theories of PCOS

Studies have shown that the hormonal environment in the uterus during pregnancy affects the endocrine state of the individual in adulthood. Exposure to high-concentration androgen environments during pregnancy, such as mothers with a history of PCOS or mothers with congenital adrenal hyperplasia and poorly controlled hyperandrogenism, can easily lead to ovulatory dysfunction after puberty.

PCOS Genetics Theory

The main basis of this theory is that PCOS tends to run in families. Familial ovulatory dysfunction and polycystic ovarian changes suggest that the disease has a genetic basis. Hyperandrogenism and/or hyperinsulinemia may be genetic characteristics that PCOS family members also suffer from. The effect of insulin in promoting ovarian androgen production is also affected by genetic factors or genetic susceptibility. Family members with oligoovulation, hyperandrogenism, and polycystic ovaries have an increased prevalence of hyperinsulinemia in women and premature hair loss in men. Cytogenetic studies have shown that PCOS may be inherited in an X-linked recessive, autosomal dominant or polygenic manner. Through whole genome scanning, the largest number of genetic genes related to PCOS were discovered, such as candidate genes for steroid hormone synthesis and related functions, androgen synthesis-related regulatory funds, insulin synthesis-related funds, candidate genes for carbohydrate metabolism and energy balance, candidate genes for gonadotropin function and regulation, adipose tissue-related genes, and chronic inflammation-related genes.

In short, the etiology research of PCOS cannot confirm that the disease is caused by a certain gene site or a certain gene mutation. Its onset may be related to the action of some genes under the influence of specific environmental factors, leading to the occurrence of the disease.