What causes poor follicular development?

If the follicles do not develop well, the first thing that will be affected is the female's fertility. The reasons for the poor follicle development are related to pituitary problems, such as prolactinoma, hyperprolactinemia, or premature ovarian failure, which will affect the development of follicles.

(1) Pituitary problems

One of the reasons for poor ovarian development and common diseases that lead to abnormal ovulation include pituitary prolactinoma, hyperprolactinemia, and Sheehan syndrome. High prolactin levels can inhibit ovulation.

(2) Hypothalamic anovulation

Primary organic factors, primary functional factors, secondary organic lesions, and secondary functional factors.

(3) Premature ovarian failure

Poor follicular development in some women is caused by premature ovarian failure. The patient has normal menstruation in the early stage and even has a history of childbearing, but then the menstruation becomes infrequent until complete amenorrhea. The follicles in the ovaries of such patients have been exhausted, and it is impossible to use ovulation-stimulating drugs to make the follicles develop, or although there are primordial follicles, they do not respond to gonadotropins.

(4) Polycystic ovary syndrome

Polycystic ovary is one of the reasons for poor follicular development. Polycystic ovary syndrome is the most common reason why women do not ovulate. The characteristics of the ovaries are that the follicles are enlarged and have multiple small follicles, but they cannot mature. Therefore, drugs are needed to promote follicle development.