What is the rate of follicle development?

What is the rate of follicular development? The rate of follicular development affects fertility. Many people may not understand the rate of follicular development, or even don’t know what it is. Female friends should know more about these aspects. Here we will popularize the knowledge in these aspects, hoping to provide more help to everyone and enable them to gain more knowledge.

The menstrual cycle is from the 6th to the 14th day, which usually lasts 8 to 10 days. At this time, some primordial follicles begin to grow and develop in the ovaries, which is called the follicular phase. (In the proliferative stage)

According to the morphological and functional changes in the process of follicle development, it can be divided into three stages: primordial follicles, growing follicles and mature follicles. The development of follicles is accelerated, the follicular phase is shortened, and menstruation will be frequent, which is likely to be accompanied by frequent menstruation! The specific situation needs to be determined in combination with various examinations and physical conditions!

Women are born with primordial follicles. Newborns have 700,000 to 2 million primordial follicles on both sides of the ovaries, and by puberty there are about 40,000 primordial follicles. Ultrasound imaging provides an effective method for detecting follicular development and ovulation, and can diagnose abnormal follicular development and various ovulation disorders more clearly. The most common abnormalities clinically are follicular dysplasia and absence of follicular development.

Follicle growth rateFolliculogenesis rate and time

Follicle growth rate (1) Time of follicle appearance: At the beginning of each menstrual cycle, multiple follicles are fertile, but generally only one or two follicles develop to maturity, called the primary follicles (dominant follicles), and the remaining follicles are closed one after another. Some authors have reported that in more than 90% of the cycles, only one follicle grows rapidly to maturity, and 5%-11% have two main follicles develop. The earliest time for ultrasound imaging of follicles can be 5-7 days in the menstrual cycle, and the minimum diameter displayed is 4-5mm.

(2) Follicle growth rate: Ultrasound can reveal small follicles in the ovaries on the 3rd to 5th day of the menstrual cycle. These follicles gradually grow larger, reaching their largest size on the 14th day on average, and ovulation can occur. From the 5th day of menstruation to before ovulation, the primary follicle grows an average of 1.5mm per day; before the 10th day, it grows an average of 1.2mm per day; 4 days before ovulation, it grows an average of 1.9mm until the follicle matures.

Mature follicles may show the following characteristics:

① The follicle is round or oval, with a diameter of 15-30mm (21.2+-0.53mm). The follicle is echo-free, clear and pure, with clear boundaries and thin walls.

② One day before ovulation, 20% of the mature follicles can be seen as a cumulus ovarian follicle, which appears as a short and strong echo near the wall of the follicle. The ultrasound measurements of the growth and development of the main follicles in 54 normal natural cycles at the Obstetrics and Gynecology Hospital are as follows

① The appearance rate of cumulus ova is about 20%, mostly appearing in mature follicles >18mm, and ovulation is predicted to occur within 24 hours.

② The sonic ring around the follicle is formed as the LH value rises, the membrane tissue edema, and the granulosa cells separate from the theca cells. Ovulation is predicted to occur within 24 hours. Ultrasound currently shows that the chance is very low.

③ The granulosa cells of the follicle wall are completely separated from the bottom layer of the membrane tissue, and the follicle wall appears serrated.

How fast does the follicle develop? The faster the follicle develops, the better. There is a normal range of values ​​for the follicle development speed, so you should pay attention to it. What is the significance of the speed of follicle development? Through the above introduction, everyone should have some understanding. The speed of follicle development is affected by the individual's body.